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intestinal epithelial cell model  (ATCC)


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    ATCC intestinal epithelial cell model
    Intestinal Epithelial Cell Model, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 15122 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/intestinal+epithelial+cell+model/Caco-2/10__1016_slash_s0168___8278_ascii40_24_ascii41_00672___x-96-14-18
    Average 99 stars, based on 15122 article reviews
    intestinal epithelial cell model - by Bioz Stars, 2026-09
    99/100 stars

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    Permeability:

    Article Title: THU-315 HSD17B13 loss-of-function splice variant delays onset of incident steatotic liver disease and suggests slower progression in established liver disease
    Article Snippet: human liver organoid model.. Method: Human liver organoids (3D InSightTM) were obtained from InSphero andwere produced fromprimary humanhepatocytes in coculture with non-parenchymal cells, including primary human Kupffer cells and primary liver endothelial cells.. Organoids were cultured in human liver lean maintenance medium (InSphero).

    Article Title: THU-316 Farnesoid X receptor agonist INT-787 exhibits high intestinal localization
    Article Snippet: enrolled in the study.. A total of 482 metabolitewere upregulated and 356 metabolite were down regulated in the plasma of SAH as compared to AC or HC (FC>1.5, p < 0.05).. Alpha and beta diversity of microbiome and mycobiome was significantly higher in SAH as compared to ACor HC (p < 0.05).

    In Vitro:

    Article Title: Deep eutectic systems from betaine and polyols – Physicochemical and toxicological properties
    Article Snippet: a Instituto de Biologia Experimental e Tecnológica, Food and Health Division, Apartado 12, 2781-901 Oeiras, Portugal b Instituto de Tecnologia Química e Biológica António Xavier, Universidade NOVA de Lisboa, Av. da República, 2780-157 Oeiras, Portugal c School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal d Laboratory for Cell Culture Technology and Biotransformations, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR10000 Zagreb, Croatia

    Bacteria:

    Article Title: Deep eutectic systems from betaine and polyols – Physicochemical and toxicological properties
    Article Snippet: a Instituto de Biologia Experimental e Tecnológica, Food and Health Division, Apartado 12, 2781-901 Oeiras, Portugal b Instituto de Tecnologia Química e Biológica António Xavier, Universidade NOVA de Lisboa, Av. da República, 2780-157 Oeiras, Portugal c School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal d Laboratory for Cell Culture Technology and Biotransformations, Faculty of Food Technology and Biotechnology, University of Zagreb, Pierottijeva 6, HR10000 Zagreb, Croatia



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    FIGURE 2 H2O2-induced cell senescence in vitro model induced CB1 reduction. (A) Morphological changes showed IEC-6 cell senescence by H2O2 treatment (150 mM) in a time-dependent manner (n=3). Scale bar, 100 mm. (B) b-gal staining indicated that positive cells (blue) increased with H2O2 treatment (150 mM) in a time-dependent manner (n=5). Scale bar, 100 mm. (C) qPCR was conducted to confirm the RNA expression of CB1 in H2O2-treated IEC-6 cells. Statistical differences were determined using t-test; a single asterisk (*) indicates p<0.05 compared to the control group. Error bars, SD (n=3). GAPDH was used for the loading control. (D, E) Western blot analysis was conducted to investigate the CB1 expression alteration by H2O2 treatment. The bar graphs represent the optical density quantification of the protein bands for each group (D, E, bottom). Statistical differences were determined using t-test; a single asterisk (*) indicates p<0.05, triple asterisks (***) indicate p<0.001 compared to control group. Error bars, SD (n=3). b-actin was used for the loading control. (F, G) CB1 mRNA expression was detected by qPCR in H2O2-treated IEC-6 cells and in cells treated with the selective CB1 inverse agonist, SR141716A (F), and/or the selective CB1 agonist ACEA (G). Statistical differences were determined using t-test; **p<0.01 and ***p<0.001 compared to control group. #p<0.05 compared to H2O2-treated group. Error bars, SD (n=3).

    Journal: Frontiers in endocrinology

    Article Title: Cannabinoid receptor type 1 in the aging gut regulates the mucosal permeability via miR-191-5p.

    doi: 10.3389/fendo.2023.1241097

    Figure Lengend Snippet: FIGURE 2 H2O2-induced cell senescence in vitro model induced CB1 reduction. (A) Morphological changes showed IEC-6 cell senescence by H2O2 treatment (150 mM) in a time-dependent manner (n=3). Scale bar, 100 mm. (B) b-gal staining indicated that positive cells (blue) increased with H2O2 treatment (150 mM) in a time-dependent manner (n=5). Scale bar, 100 mm. (C) qPCR was conducted to confirm the RNA expression of CB1 in H2O2-treated IEC-6 cells. Statistical differences were determined using t-test; a single asterisk (*) indicates p<0.05 compared to the control group. Error bars, SD (n=3). GAPDH was used for the loading control. (D, E) Western blot analysis was conducted to investigate the CB1 expression alteration by H2O2 treatment. The bar graphs represent the optical density quantification of the protein bands for each group (D, E, bottom). Statistical differences were determined using t-test; a single asterisk (*) indicates p<0.05, triple asterisks (***) indicate p<0.001 compared to control group. Error bars, SD (n=3). b-actin was used for the loading control. (F, G) CB1 mRNA expression was detected by qPCR in H2O2-treated IEC-6 cells and in cells treated with the selective CB1 inverse agonist, SR141716A (F), and/or the selective CB1 agonist ACEA (G). Statistical differences were determined using t-test; **p<0.01 and ***p<0.001 compared to control group. #p<0.05 compared to H2O2-treated group. Error bars, SD (n=3).

    Article Snippet: Cell culture & in vitro cell senescence model Normal rat small intestinal epithelial cells (IEC-6; cat. no. CRL1592) and the human colonic epithelial adenocarcinoma cell line Caco-2 (cat. no. HTB-37TM) were purchased from American Type Culture Collection (Manassas, VA, USA).

    Techniques: In Vitro, Staining, RNA Expression, Control, Western Blot, Expressing

    FIGURE 3 Intestinal permeability and tight junction protein expression were regulated by CB1 signaling modulation. (A) Morphological changes showed IEC-6 cell senescence by H2O2 and SR141716A treatment (n=5). Scale bar, 100 mm. (B) The TEER values were detected in H2O2-treated IEC-6 cells and cells treated with the CB1 inverse agonist SR141716A. The bar graph indicated the TEER values at 24 h (B, right). Statistical differences were determined using t-test; ***p<0.001 compared to control group. Error bars, SD (n=3). (C) Morphological changes showed IEC-6 cell senescence caused by H2O2 and the restoration of cell morphology with ACEA treatment after 24 h and 48 h (n=5). Scale bar, 100 mm. (D) The decreased TEER values caused by H2O2 treatment were increased by co-treatment with the CB1 agonist ACEA. The bar graph presents the TEER values at 24 h after treatment with H2O2 and ACEA (D, right). Statistical differences were determined using t-test; ***p<0.001 compared to control group and ###p<0.001 compared to H2O2- treated group. Error bars, SD (n=3). (E, F) The mRNA expression levels of the tight junction proteins ZO-1, ZO-2, Claudin-2, Claudin-4 and Occludin were detected by RT-PCR in H2O2-treated IEC-6 cells. RT-PCR results showed a decrease in the levels of these tight junction proteins (E) and the bar graph presents the band intensity of the RT-PCR results (F). Statistical differences were determined using t-test; *p<0.05, **p<0.01, and ***p<0.001 compared to control group. Error bars, SD (n = 3). GAPDH was used for the loading control. (G) Decreased RNA expression of ZO-1 by H2O2 was restored by ACEA co-treatment. The bar graphs present the band intensity of PCR results. Statistical differences were determined using t-test; *p<0.05 compared to control group and #p<0.05 compared to H2O2-treated group. Error bars, SD (n = 3).

    Journal: Frontiers in endocrinology

    Article Title: Cannabinoid receptor type 1 in the aging gut regulates the mucosal permeability via miR-191-5p.

    doi: 10.3389/fendo.2023.1241097

    Figure Lengend Snippet: FIGURE 3 Intestinal permeability and tight junction protein expression were regulated by CB1 signaling modulation. (A) Morphological changes showed IEC-6 cell senescence by H2O2 and SR141716A treatment (n=5). Scale bar, 100 mm. (B) The TEER values were detected in H2O2-treated IEC-6 cells and cells treated with the CB1 inverse agonist SR141716A. The bar graph indicated the TEER values at 24 h (B, right). Statistical differences were determined using t-test; ***p<0.001 compared to control group. Error bars, SD (n=3). (C) Morphological changes showed IEC-6 cell senescence caused by H2O2 and the restoration of cell morphology with ACEA treatment after 24 h and 48 h (n=5). Scale bar, 100 mm. (D) The decreased TEER values caused by H2O2 treatment were increased by co-treatment with the CB1 agonist ACEA. The bar graph presents the TEER values at 24 h after treatment with H2O2 and ACEA (D, right). Statistical differences were determined using t-test; ***p<0.001 compared to control group and ###p<0.001 compared to H2O2- treated group. Error bars, SD (n=3). (E, F) The mRNA expression levels of the tight junction proteins ZO-1, ZO-2, Claudin-2, Claudin-4 and Occludin were detected by RT-PCR in H2O2-treated IEC-6 cells. RT-PCR results showed a decrease in the levels of these tight junction proteins (E) and the bar graph presents the band intensity of the RT-PCR results (F). Statistical differences were determined using t-test; *p<0.05, **p<0.01, and ***p<0.001 compared to control group. Error bars, SD (n = 3). GAPDH was used for the loading control. (G) Decreased RNA expression of ZO-1 by H2O2 was restored by ACEA co-treatment. The bar graphs present the band intensity of PCR results. Statistical differences were determined using t-test; *p<0.05 compared to control group and #p<0.05 compared to H2O2-treated group. Error bars, SD (n = 3).

    Article Snippet: Cell culture & in vitro cell senescence model Normal rat small intestinal epithelial cells (IEC-6; cat. no. CRL1592) and the human colonic epithelial adenocarcinoma cell line Caco-2 (cat. no. HTB-37TM) were purchased from American Type Culture Collection (Manassas, VA, USA).

    Techniques: Permeability, Expressing, Control, Reverse Transcription Polymerase Chain Reaction, RNA Expression

    FIGURE 7 Reduction of CB1 in aged intestinal epithelial cells caused tight junction dysfunction. Decreased CB1 is associated with the induction of miR-191-5p. miR-191-5p reduced ZO-1 expression by targeting directly and via activation of p-p65 NF-kB transcription factor.

    Journal: Frontiers in endocrinology

    Article Title: Cannabinoid receptor type 1 in the aging gut regulates the mucosal permeability via miR-191-5p.

    doi: 10.3389/fendo.2023.1241097

    Figure Lengend Snippet: FIGURE 7 Reduction of CB1 in aged intestinal epithelial cells caused tight junction dysfunction. Decreased CB1 is associated with the induction of miR-191-5p. miR-191-5p reduced ZO-1 expression by targeting directly and via activation of p-p65 NF-kB transcription factor.

    Article Snippet: Cell culture & in vitro cell senescence model Normal rat small intestinal epithelial cells (IEC-6; cat. no. CRL1592) and the human colonic epithelial adenocarcinoma cell line Caco-2 (cat. no. HTB-37TM) were purchased from American Type Culture Collection (Manassas, VA, USA).

    Techniques: Expressing, Activation Assay